Carafate and Synthroid Interactions
It may be necessary to change a medication or dosage to prevent harm. Levothyroxine is a man-made form of the human thyroid hormone called T4. It is given to people who do not produce enough of their own thyroid hormone (hypothyroidism). Sucralfate can heal an active ulcer, but it will not prevent future ulcers from occurring. In a multicenter, double-blind, placebo-controlled study of CARAFATE Oral Suspension, a dosage regimen of 1 gram (10 mL) four times daily was demonstrated to be superior to placebo in ulcer synthroid cinnamon healing.
- Get medical help right away, if you have any of the symptoms listed above.
- Ranitidine is used to treat and prevent ulcers in the stomach and intestines.
- In addition, there are several drugs that can interfere with drug absorption including phosphate binders, orlistat, proton pump inhibitors, sucralfate, and antacids (See a complete list here – 7).
- In addition, aluminum does not cross dialysis membranes because it is bound to albumin and transferrin plasma proteins.
- If you are taking this drug combination, it is very important to be under close medical supervision to minimize severe side effects and ensure your safety.
- While Lithobid (lithium) has the potential to interact with many drugs including SSRIs, NSAIDs, ACE inhibitors, just to name a few, it does not appear to interact with Synthroid.
Levothyroxine with Sucralfate Interaction Details
Enter medications to view a detailed interaction report using our Drug Interaction Checker. Carafate is not greatly absorbed into the body through the digestive tract. It works mainly in the lining of the stomach by sticking to ulcer sites and protecting them from acids, enzymes, and bile salts. You are encouraged to report negative side effects of prescription drugs to the FDA. These observations suggest that sucralfate’s antiulcer activity is the result of formation of an ulcer- adherent complex that covers the ulcer site and protects it against further attack by acid, pepsin, and bile salts. There are approximately 14 to 16 mEq of acid-neutralizing capacity per 1 g dose of sucralfate.
What Drugs, Substances, or Supplements Interact with Carafate?
Provides a detailed discussion on how patients and clinicians can approach the identified drug interaction as well as offers guidance on what to expect and strategies to potentially mitigate the effects of the interaction. This may include recommendations on adjusting medication dosages, altering the timing of drug administration, or closely monitoring for specific symptoms. Levothyroxine is widely used totreat patients with thyroid disorders.Unfortunately, the bioavailabilityof levothyroxine can be reducedby a variety of other medications, leadingto reduced levothyroxine effect. Onewould expect that thyroid hormonesother than levothyroxine would interactsimilarly with the drugs described inthis article.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Carafate only for the indication prescribed.
- Teratogenicity studies have been performed in mice, rats, and rabbits at doses up to 50 times the human dose and have revealed no evidence of harm to the fetus due to sucralfate.
- However, this still may not entirely avoid the interaction and may not always be feasible.
- It works mainly in the lining of the stomach by sticking to ulcer sites and protecting them from acids, enzymes, and bile salts.
- Your doctor may adjust your dose based on your blood sugar levels.
Lansoprazole is used to treat stomach and intestinal ulcers, erosive esophagitis and … Ranitidine is used to treat and prevent ulcers in the stomach and intestines. Ask your doctor before using an antacid, and use only the type your doctor recommends. Some antacids can make it harder for sucralfate to work in your stomach. Avoid taking an antacid within 30 minutes before or after taking Carafate.
Consequently, TSH levels should be monitored approximately 6 to 8 weeks after initiating treatment and dose changes. In general, it is not necessary to discontinuethe drug that is reducing levothyroxineabsorption (see box above right). The interactionsgenerally can be circumvented byappropriate adjustment of the dosingtimes of the levothyroxine relative tothe binding agents. Add your drug list to My Med List to view medical information in a simple, easy-to-read, personalized format. Automatically receive FDA alerts, drug interaction warnings, plus data on food, allergy & condition interactions. A reproduction study in rats at doses up to 38 times the human dose did not reveal any indication of fertility impairment.
Cases of bronchospasm, laryngeal edema and respiratory tract edema have been reported with an unknown oral formulation of sucralfate. This interaction has the potential to worsen your medical condition or alter the effectiveness of your treatment. It’s important that you are monitored closely and you potentially may need to make adjustments in your treatment plan or drug dosage to maintain optimal health. Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
If you are unsure whether one of your medicines interacts with levothyroxine, talk to your doctor or pharmacist. Make sure to always give all of your healthcare providers a full list of your medications (prescription and nonprescription) and any supplements you take. This will help you and your doctors to evaluate all possible interactions and come up with a plan to avoid or minimize them.
Adverse reactions to sucralfate tablets in clinical trials were minor and only rarely led to discontinuation of the drug. In studies involving over 2700 patients treated with sucralfate, adverse effects were reported in 129 (4.7%). MW is a 38-year-old female who presents to your community pharmacy with a new prescription for Synthroid. She explains that she had been experiencing fatigue, hair loss, and constipation so she scheduled an appointment with her doctor. Laboratory findings and symptoms confirmed the presence of hypothyroidism. The patient’s PMH is significant for hyperlipidemia, diabetes, gastric ulcers, bipolar disorder, and obesity.
Sucralfate is only minimally absorbed from the gastrointestinal tract. The small amounts of the sulfated disaccharide that are absorbed are excreted primarily in the urine. This document does not contain all possible side effects and others may occur.
It may take 2 to 8 weeks before you receive the full benefit of taking Carafate. Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Your doctor may adjust your dose based on your blood sugar levels. Safety and effectiveness in pediatric patients have not been established.
